EVOLUTIONARY THEORIES OF AGING AND THE DEVELOPMENT OF LONGEVITY SCIENCE
Abstract
Abstract: The process of aging is deeply embedded in the biology of all living organisms and has been a subject of scientific research and philosophical reflection for centuries. This article explores the historical evolution of aging theories, focusing on evolutionary perspectives, and examines various concepts of longevity extension. Key evolutionary theories discussed include programmed death (Weismann), mutation accumulation (Medawar), antagonistic pleiotropy (Williams), and the disposable soma theory (Kirkwood and Holliday). Longevity concepts range from immortalism and radical longevity to transhumanism, posthumanism, singularity, and bioconservatism. The article includes comparative tables and illustrative graphics to enhance understanding. The goal is to provide a comprehensive framework for the potential business development of longevity technologies, integrating historical context, scientific achievements, and economic prospects.
References
2. Baumrind, D. (1971). Current patterns of parental authority. Developmental Psychology Monograph, 4(1), 1–103.
3. Blasco, M. A., López-Otín, C., Partridge, L., Serrano, M., & Kroemer, G. (2023). Hallmarks of aging: An expanding universe. Cell, 186(2), 243–278. https://doi.org/10.1016/j.cell.2022.11.001
4. Blüher, M., Kahn, B. B., & Kahn, C. R. (2003). Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (New York, N.Y.), 299(5606), 572–574. https://doi.org/10.1126/science.1078223
5. Bostrom, N., & Roache, R. (2010). Ethical issues in human enhancement. In J. Ryberg, T. Petersen, & C. Wolf (Eds.), New waves in applied ethics. Palgrave Macmillan.
6. Buettner, D., & Skemp, S. (2015). Blue Zones: Lessons from the world’s longest lived. American Journal of Lifestyle Medicine, 10(5), 318–321. https://doi.org/10.1177/1559827616637066
7. Burger, O., Baudisch, A., & Vaupel, J. (2012). Human mortality improvement in evolutionary context. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1210185110
8. Carey, J. R., & Judge, D. S. (2001). Life span extension in humans is self-reinforcing: A general theory of longevity. Population and Development Review, 27(3), 411–436.
9. Clarke, S., Savulescu, J., & Coady, T. (Eds.). (2016). The ethics of human enhancement: Understanding the debate. Oxford University Press.
10. Darwin, C. (1859) On the Origin of Species by Means of Natural Selection, or, The Preservation of Favoured Races in the Struggle for Life. J. Murray, London.
11. Ekerdt, D. J. (2002). Encyclopedia of aging. Macmillan Reference USA.
12. Friedman, D. B. , & Johnson, T. E. (1988). A mutation in the age‐1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics, 118, 75–86.
13. Gavrilov, L. A., & Gavrilova, N. S. (2002). Evolutionary theories of aging and longevity. Scandinavian Journal of Theoretical Biology, 2(3).
14. George, A. S. (1978). Longevity and aging in vertebrate evolution. BioScience, 28(8), 497–501. https://doi.org/10.2307/1307295
15. Gittleman, A. L. (2021). Radical longevity: The powerful plan to sharpen your brain, strengthen your body, and reverse the symptoms of aging. Hachette Go.
16. Goldsmith T. C. (2004). Aging as an evolved characteristic - Weismann's theory reconsidered. Medical hypotheses, 62(2), 304–308. https://doi.org/10.1016/S0306-9877(03)00337-2
17. Goldwasser, L. (2001). The biodemography of life span: Resources, allocation and metabolism. Trends in Ecology & Evolution, 16, 536–538.
18. Guarente, L., & Kenyon, C. (2000). Genetic pathways that regulate ageing in model organisms. Nature, 408(6809), 255–262. https://doi.org/10.1038/35041700
19. Gundry, S. R. (2019). The longevity paradox: How to die young at a ripe old age. HarperWave.
20. Harari, Y. N. (2017). Homo Deus: A brief history of tomorrow. HarperCollins Publishers.
21. Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., Pahor, M., Javors, M. A., Fernandez, E., & Miller, R. A. (2009). Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature, 460(7253), 392–395. https://doi.org/10.1038/nature08221
22. Kirkwood T. B. (1977). Evolution of ageing. Nature, 270(5635), 301–304. https://doi.org/10.1038/270301a0
23. Kurzweil, R. (2005). The singularity is near: When humans transcend biology. Viking.
24. Le Bourg, E. (1998). Evolutionary theories of aging: Handle with care. Gerontology, 44(6), 345–348. https://doi.org/10.1159/000022040
25. Lin, Y. J., Seroude, L., & Benzer, S. (1998). Extended life-span and stress resistance in the Drosophila mutant methuselah. Science (New York, N.Y.), 282(5390), 943–946. https://doi.org/10.1126/science.282.5390.943
26. Longo, V. D., Mitteldorf, J., & Skulachev, V. P. (2005). Programmed and altruistic ageing. Nature reviews. Genetics, 6(11), 866–872. https://doi.org/10.1038/nrg1706
27. McAuley, M. T. (2024). The evolution of ageing: Classic theories and emerging ideas. Biogerontology, 26.
28. Medawar, P. B. (1952). An unsolved problem of biology: An inaugural lecture delivered at University College, London, 6 December, 1981. H. K. Lewis.
29. More, M., & Vita-More, N. (2013). The transhumanist reader: Classical and contemporary essays on the science, technology, and philosophy of the human future. Wiley-Blackwell.
30. Nietzsche, F. W. (2007). On the genealogy of morality (K. Ansell-Pearson & C. Diethe, Eds.). Cambridge University Press.
31. Noordam, R., Gunn, D., Tomlin, C., Rozing, M., Maier, A., Slagboom, P., & Craen, A. (2012). Cortisol serum levels in familial longevity and perceived age: The Leiden Longevity Study. Psychoneuroendocrinology, 37(1), 1669–1675. https://doi.org/10.1016/j.psyneuen.2012.02.015
32. Redman, L., Smith, S., Burton, J., Martin, C., Llyasova, D., & Ravussin, E. (2018). Metabolic slowing and reduced oxidative damage with sustained caloric restriction support the rate of living and oxidative damage theories of aging. Cell Metabolism, 27(1), 805–815.
33. Sacher, G. A. (1978). Longevity and aging in vertebrate evolution. BioScience, 28(8), 497–501. https://doi.org/10.2307/1307295
34. Sandel, M. J. (2007). The case against perfection: Ethics in the age of genetic engineering. Belknap Press.
35. Schutte, N., Palanisamy, S., & McFarlane, J. (2016). The relationship between positive psychological characteristics and longer telomeres. Psychology & Health, 31(12), 1466–1480. https://doi.org/10.1080/08870446.2016.1226308
36. Soerensen, M., Thinggaard, M., Nygaard, M., Dato, S., Tan, Q., Hjelmborg, J., & Christiansen, L. (2012). Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: A cross-sectional and longitudinal analysis. Aging Cell, 68(1), 223–227.
37. Stearns, S. C. (1998). The evolution of life histories. Oxford University Press.
38. Suzuki, M., Willcox, B., & Willcox, C. (2005). The Okinawa diet plan. Clarkson Potter.
39. Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2023). Aging hallmarks and progression and age-related diseases: A landscape view of research advancement. ACS Chemical Neuroscience, 15, 1–30.
40. Vita-More, N. (2020). The transhumanist manifesto (Version 4). Humanity+.
41. Walford, R. (2000). Beyond the 120-year diet: How to double your vital years. London.
42. Wang, J., Shi, L., Zou, Y., Tang, J., Cai, J., Wei, Y., & Zhang, Z. (2018). Positive association of familial longevity with moderate-high HDL-C concentration in Bama Aging Study. Aging, 10(11), 3528–3540. https://doi.org/10.18632/aging.101663
43. Williams, G. C. (1957). Pleiotropy, natural selection, and the evolution of senescence. Evolution, 11(4), 398–411. https://doi.org/10.2307/2406060
44. Willcox, B., Willcox, C., & Suzuki, M. (2001). The Okinawa program. Clarkson Potter.

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